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A Baltimore startup that's developing a medical device to treat migraine headaches is in talks to be acquired by a global medical device company.

Baltimore’s eNeura Inc. has entered into an agreement with Orthofix International N.V. that gives the Texas medical device firm 18 months to decide whether it wants to acquire eNeura for $65 million. As part of the deal, Orthofix is giving eNeura a $15 million loan to support commercialization of its migraine management device, Spring TMS.