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All it takes is one hit. And Christy Wyskiel likes her chances.

Johns Hopkins University, where Wyskiel heads up technology commercialization, is among the institutions scrambling to transform more faculty research into startup companies, patents and licenses. Hopkins in 2014 reported $16.5 million in licensing revenue, but is still far behind universities that have been leaders in commercialization. Columbia University, for example, earned $150 million in licensing revenue last year.