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Philadelphia’s old brick residential neighborhoods aren’t the only part of the city that’s being gentrified.

The same thing is happening to University City’s rental lab space, where some rents are quadrupling. It’s a sign of success and the flood of investment boosting biotech firms. But it’s also a threat to startups that could force brainy startup leaders to flee to cheap space in the suburbs or go out of state, some university officials, start-up founders and young scientists say.