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William E. (Brit) Kirwan, chancellor of the University System of Maryland and a longtime national figure in public higher education, will resign from his leadership post when a successor is named, Mr. Kirwan announced on Tuesday.

Mr. Kirwan, who is 76, has led the Maryland system for 12 years and served as president of Ohio State University from 1998 to 2002. He has been at the forefront of national conversations about reducing college costs, including athletics spending.