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AstraZeneca on Monday rejected a "final" $119 billion buyout offer from Pfizer, possibly sinking a pharmaceutical mega-merger that could have jeopardized jobs at AZ's Maryland subsidiary, MedImmune.

Pfizer, which would have created the world's largest drug company through the deal, on Sunday evening increased its earlier $106 billion cash-and-stock bid. In a statement, AstraZeneca Chairman Leif Johansson called that new offer "inadequate" and said it would have "serious consequences for the company, our employees and the life-sciences sector in the U.K., Sweden and the U.S."