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MedImmune's Gaithersburg headquarters will gain 300 new jobs under a broader U.S. consolidation by parent company AstraZeneca PLC, the companies announced Monday.

The move follows management changes at both companies. Pascal Soriot was named AstraZeneca CEO in August, and early this year carried out a leadership shuffle that included installing Bahija Jallal as MedImmune's new chief. She replaces Peter Greenleaf, who is heading AZ's Latin American unit.