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Eight years of work, thousands of researchers around the world, $1 billion spent — and finally it was done. On April 14, 2003, a decade ago this week, scientists announced that they had completed the Human Genome Project, compiling a list of the three billion letters of genetic code that make up what they considered to be a sort of everyperson’s DNA.

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The need for innovation in healthcare has arguably never been greater.  A range of factors, from aging world populations to rising standards of living in developing countries, are poised to drive long-run demand for innovative drugs, devices and medical technologies that can improve outcomes and reduce costs.

Ironically, however, funding for healthcare innovation remains in short supply.  As industry participants are keenly aware, life science venture capital financing – which has played a critical role in helping translate research ideas into commercially useful medical technologies – is becoming increasingly scarce.

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Cleave Biosciences has added $10 million in Series A financing from new investor New Enterprise Associates, bringing its Series A total to $54 million. In the fall of 2011, Cleave raised $44 million from US Venture Partners, 5AM Ventures, Clarus Ventures, OrbiMed Advisors, Astellas Venture Management and Osage University Partners. The company is focused on cancer drug discovery and development.

Cleave is discovering novel drugs that affect protein degradation pathways. Cancer cells frequently make an excess of proteins and hence become dependent on protein degradation for their survival. By attacking key targets in these pathways, cancer cells fail to balance this excess protein synthesis with protein degradation and can no longer survive.

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Maryland U.S. Senator Barbara A. Mikulski plans to participate in a signing ceremony at the National Institute of Standards and Technology for new private sector partners that will collaborate with the National Cybersecurity Center of Excellence on Monday, April 15.

According to a statement from the senator’s office:

The new partners will pledge to contribute hardware and software components and share cybersecurity best practices and personnel with the center in an effort to address current cybersecurity threats. Senator Mikulski will be joined by Governor Martin O’Malley, Montgomery County Executive Ike Leggett, Commander of U.S. Cyber Command and NSA Chief General Keith B. Alexander, and Under Secretary of Commerce for Science and Technology and NIST Director Patrick Gallagher …

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When he was young, Daniel J. Abdun-Nabi wasn’t all that interested in subjects like biology. He gravitated toward political science and the law in college, and worked for the federal Securities and Exchange Commission soon after graduating.

“I went out of my office and saw the Capitol. It was awe-inspiring,” Abdun-Nabi, 58, who grew up near Boston, said of working in Washington, D.C.

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The Tech Council of Maryland (TCM), Maryland’s largest technology trade association with more than 400 biotechnology and technology members employing more than 200,000 in the region, today commended state policy makers for advancing key priorities for the tech community during this year’s legislative session. The 2013 session concluded on Tuesday.

“Maryland’s policy makers delivered on our biggest priorities: stronger incentives for R&D and biotechnology, new incentives for cybersecurity investments, and corporate tax code certainty for employers,” said Larry Letow, TCM’s chairman. “We have many strong advocates in Annapolis who understand that Maryland’s technology and biotechnology companies are catalysts for innovation, job growth and prosperity.”

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Friday, May 24 • 12:00 - 2:00 pm • Marriott Bethesda North Conference Center

Join the Montgomery County Department of Economic Development to celebrate small businesses. Attend the inaugural Small Business Awards program.

The award luncheon will provide countless opportunities to show your appreciation for the estimated 33,000 small businesses of Montgomery County—businesses that contribute directly to the strength of the area's economy. Eight awards will be presented to eight distinct companies.

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The Global Virus Network plans to move its headquarters to the University of Maryland BioPark in Baltimore, officials announced Thursday.

Emerging pandemic viral threats and current viral killers are a worldwide problem. For this reason, the nonprofit  GVN brings together the top medical virologists from more than 30 institutions in 21 countries, to promote international collaborative research, education and advocacy.

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David Mott at New Enterprise Associates has spearheaded the development of an orphan drug accelerator that plans to hunt down the best in vivo-stage assets in academia, biopharma and the nonprofits, assemble them in a portfolio of rare disease therapies and mold them into pipeline programs that can be spun out into a slate of new biotech companies.

NEA's high-profile biotech partner Mott--who helmed MedImmune until AstraZeneca ($AZN) came along and scooped it up for $15.6 billion--partnered with Pfizer Ventures and gained the support of Alexandria Real Estate Equities in piecing together the initial $16 million in startup funds for the newly coined Cambridge, MA-based Cydan.

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GlaxoSmithKline, Britain's biggest drugmaker, is placing a small but important bet on a new way of treating diseases by targeting electrical signals in the body.

The company said on Wednesday it would offer a $1 million prize to stimulate innovation in the field, as well as funding up to 40 researchers working in external laboratories.

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The University of Maryland (UM) BioPark announced today that the Global Virus Network (GVN) is the Park’s newest tenant. The GVN is a non-profit organization comprised of the top medical virologist in more than 30 institutions spanning 21 nations – and growing. GVN's mission is to combat emerging pandemic viral threats and current viral killers through international collaborative research, training the next generation of medical virologist, education and advocacy.   

Said Jim Hughes, President, Research Park Corporation, University of Maryland Baltimore, “It’s exciting for the UM BioPark to include the prestigious Global Virus Network as one of our tenants. We are also pleased to be able to offer GVN continued close proximity to its Scientific Director, Co-Founder, and world-renowned virus researcher Dr. Robert Gallo from the UM School of Medicine, whose Institute of Human Virology is located conveniently just down the street from the GVN’s new BioPark headquarters.” 

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Pluristem Therapeutics (NASDSQ: PSTI) announced today that following favorable preclinical studies, United Therapeutics Corporation received approval to perform a human Phase I study in Australia using Pluristem's PLacental eXpanded (PLX-PAD) cells in patients diagnosed with Pulmonary Arterial Hypertension (PAH). On June 20, 2011 United Therapeutics and Pluristem entered into a licensing agreement pursuant to which United Therapeutics will develop, market and sell Pluristem's PLX-PAD cells for PAH.

PAH is characterized by abnormally high blood pressure in the arteries of the lungs and leads to an increased workload on the right side of the heart.

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Pieris AG and The Sanofi Group have jointly agreed to expand their ongoing discovery and development partnership to include a novel multispecific Anticalin® program. Under the existing framework of the 2010 agreement, the new program will entitle Pieris to an upfront payment from Sanofi and committed research funding as well as payments for the achievement of research, preclinical, regulatory and commercial milestones. Specific financial terms were not disclosed.

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A test that detects human papillomavirus, a virus directly related to cervical cancer, has hit the market following approval by the China Food and Drug Administration.

"The careHPV test is faster, better and cheaper," says Qiao Youlin, a respected epidemiologist, who headed a research project into the development of careHPV between 2003 and 2008. The research was assisted by the Bill & Melinda Gates Foundation, which contributed $13 million to the project.

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Company: MedImmune Booth/Stand: 3344 Event: 2013 BIO International ConventionApr 22 - 25 2013 Chicago IL US

About MedImmune

MedImmune is the worldwide biologics research and development arm of AstraZeneca a global innovation-driven biopharmaceutical business that focuses on the discovery development and commercialization of small molecule and biologic prescription medicines. MedImmune is pioneering innovative research and exploring novel pathways across key therapeutic areas including respiratory inflammation and autoimmunity; cardiovascular and metabolic disease; oncology; neuroscience; and infection and vaccines. MedImmune has approximately 2500 employees globally with its headquarters located in Gaithersburg Md. one of AstraZeneca’s three global R&D centers. For more information please visit www.medimmune.com.

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When engineers at this university learned of a Baltimore neurosurgeon’s struggle to operate on sensitive parts of the brain, they designed a tiny robot to maneuver around more precisely than instruments held by a human hand during surgery — something Loh said never would have happened if the neurosurgeon and robotic engineers had not met. Now, one year into the partnership, the universities have launched a collaborative public health school, developed a joint biomedical informatics and bioimaging center and created a research and innovation program.

“When you have a formal structure for a partnership and encourage people to talk to each other, this is what the partnership between the universities is all about,” Loh said. “They have the problems; we have the solutions.”

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I launched a literary magazine in college. I actually thought that was a good idea. After a few too many 16-hour days of hustling ads and desperately scrounging for content, my grades tanked and my blood pressure skyrocketed. I learned that special kind of panic that comes from trying to execute on the inflated ambitions of a 20-year-old. The process consumed everything. (For the record, I regret nothing.)

My point is: The university setting is great for being entrepreneurial. But it takes organization and drive to hold it all together — something I realized I didn't have. At least some of these young founders do.

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The Tech Council of Maryland (TCM), Maryland’s largest technology trade association with more than 400 biotechnology and technology members employing more than 200,000 in the region, announced the finalists for its 25th Annual Dinner and Awards Celebration. Winners will be announced at the awards dinner on May 16 at the Bethesda North Marriott Hotel and Conference Center.

“This year’s finalists are a testament to the ingenuity and vibrancy of Maryland’s technology and life sciences community,” said Larry Letow, TCM’s chairman. “Their innovations advance the cause of a healthier, safer world while fostering job creation and prosperity here in Maryland. Simply put, Maryland’s tech and biotech companies are essential to our long-term economic growth. The TCM’s Awards Celebration is a great way to celebrate our members’ tremendous achievements to date and the bright future that lies ahead.”

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Nominate your best startups to present to a select group of invitation-only investors and Global 1000 companies as part of the Virtual Startups Showcase (VSS) and the Exits Startups Showcase + Conference in San Francisco

NOMINATION DEADLINES

  • For University Startups: Friday, April 26, 2013
  • For Accelerator, Angel Investor and VC Portfolio Companies: Friday, June 14, 2013

The National Council on Entrepreneurial Tech Transfer (NCET2) asks universities, accelerators, Angel investors and VC's to nominate their best startups and have them present to a select group of invitation-only investors and Global 1000 companies.

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WIScience Scholarship: The Premier Catalyst for Developing Women Leaders in Science

Are you nearing completion of your graduate degree or fellowship, and wondering how you’re going to transition into the healthcare industry? Do you get nervous thinking about how to identify the career in healthcare that fits you best?  Do you wish you had a mentor to discuss these concerns with?  If so, then you are the perfect candidate to apply for the WIScience Scholarship: The Premier Catalyst for Developing Women Leaders in Science offered by the Mid-Atlantic chapter of the Healthcare Businesswomen’s Association (HBA). 

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The Maryland House of Delegates has passed a measure to adjust how money from a state venture capital fund can be used to try to make it more effective.

The House voted 107-25 on Saturday for the bill. That sends it to the Senate to consider amendments delegates made to the measure.

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Those who join MedImmune feel a sense of ownership about their future. They thrive with a recognized leader in the biotechnology industry and the wholly-owned subsidiary of AstraZeneca plc.

Here, you will join passionate professionals who advance science, technology and medicine to develop products designed to help people live better lives. You will excel in an environment characterized by respect, integrity and growth opportunities…that encourages both individual contribution and collaborative entrepreneurial thinking. Our products and/or product candidates are designed to address areas of need in infection, oncology, respiratory disease and inflammation, cardiovascular/gastrointestinal disease and neuroscience. Explore a MedImmune career as we strive to better more lives, more often, around the world.

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GlaxoSmithKline ( GSK ) recently announced that it has initiated a phase III study to evaluate the use of Benlysta (belimumab) in patients suffering from anti-neutrophil cytoplasmic antibodies (ANCA) positive vasculitis.

The multi-centre, randomized, double-blind phase III study will assess the efficacy and safety profile of Benlysta in combination with azathioprine as a maintenance therapy in ANCA positive vasculitis patients.

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There’s an interesting trend I’ve noticed with at least one healthcare accelerator I have been tracking. The members of the startups for the most part have increasingly more industry experience and seem more adept at finding pain points and delivering a workable solution to members of the healthcare ecosystem. And if the successes of Blueprint Health’s latest graduating class are anything to go by, healthcare companies are getting increasingly receptive to working with startups that can help them address some of the demands of the Affordable Care Act and some of its impacts with more innovative solutions.

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Seeking to maximize ongoing research, innovative ideas and revenue-generating opportunities, more schools are creating entrepreneur-in-residence programs -- and letting the experts do the work.

With millions of dollars of research funding and teams of experts at their disposal, more universities are seeking ways to turn research breakthroughs into business opportunities.

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Among 400 applications from 22 countries, 13 early stage healthcare companies have been chosen for a three-year entrepreneurship class run by StartUp Health and GE, according to a statement from the companies. The class members will each be assigned a GE mentor who matches their business model and get access to the resources the Fortune 50 company can wield to help scale their consumer health innovations. That could include working with GE Healthymagination, GE Healthcare, GE Capital, or some of its business units, depending on the members’ specific needs.

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AstraZeneca 's ( AZN ) worldwide biologics research and development (R&D) unit, MedImmune recently acquired AlphaCore Pharma, a biotechnology company based in Michigan. Financial terms of the deal were not disclosed by the companies.

We note that the acquisition of AlphaCore Pharma adds ACP-501 (a recombinant human lecithin-cholesterol acyltransferase/ LCAT enzyme) to AstraZeneca's pipeline. The candidate is being developed for acute coronary syndromes (ACS) and other high-risk atherosclerosis conditions for the rapid removal of tissue cholesterol.

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Digital health incubator Rock Health released data today that shows an increase in funding for med-tech startups in the first quarter of 2013.

Thirty-seven health deals were valued at a total of $365 million, which is 35 percent higher than the first quarter of 2012, “suggesting that 2013 will be another record year for the digital health industry,” the blog post reads.

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A big-data revolution is under way in health care. Start with the vastly increased supply of information. Over the last decade, pharmaceutical companies have been aggregating years of research and development data into medical databases, while payors and providers have digitized their patient records. Meanwhile, the US federal government and other public stakeholders have been opening their vast stores of health-care knowledge, including data from clinical trials and information on patients covered under public insurance programs. In parallel, recent technical advances have made it easier to collect and analyze information from multiple sources—a major benefit in health care, since data for a single patient may come from various payors, hospitals, laboratories, and physician offices.

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Johns Hopkins researcher Se-Jin Lee was named Wednesday as the 2013 recipient of the Ho-Am Prize in Medicine, which recognizes outstanding accomplishments in medical research that pave the way to conquering disease. It is awarded each year to an ethnic Korean and is sometimes referred to as “Korea's Nobel.”

Lee is best known for his discovery of myostatin, a hormone that regulates muscle mass, and related work that lays the foundation for new therapies for conditions such as muscle wasting and muscular dystrophy.

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Philadelphia has reached a milestone in its efforts to be recognized as a healthcare and life sciences hub with the start of its first health IT accelerator.

DreamIt Health’s inaugural class includes 10 startups. The four-month program co-sponsored by Independence Blue Cross and Penn Medicine includes members seeking to develop tools for healthcare providers to speed up diagnoses and improve outcomes.

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Maryland has invested $500,000 in Cytomedix Inc., a regenerative medicine company in Gaithersburg.

The investment was made through the state's Maryland Venture Fund and InvestMaryland program. The state said the money is part of a $27.5 million fundraising round by Cytomedix (OTC: CMXI) that will result in the company adding 13 new employees to its current staff of 55.