Germantown-based Intrexon Corp. a synthetic biology company, plans to raise up to $150 million though a secondary offering of common stock, the company said late Tuesday.

Intrexon (NYSE: XON) was trading at around $29 a share Wednesday.

Washington, D.C.-based REGENXBIO Inc., announced today that it had completed a $30 million Series C financing. The round was led by Enrick and Brookside Capital. Also participating were Deerfield Management and an unnamed new investor.

Following AstraZeneca's December announcement that it is taking steps to reintroduce the EGFR-targeted non-small cell lung cancer drug Iressa (gefitinib) in the US, Qiagen said last week that it would develop a tissue-based molecular diagnostic test to accompany the drug's launch.

Venture capital investment soared in 2014, hitting a high that hasn’t been seen since 2000. As reported in The Wall Street Journal, $52.12 billion was invested in private companies last year by venture and private equity firms, as well as corporations, hedge funds and mutual funds, according to Dow Jones VentureSource.

The National Heart, Lung, and Blood Institute (NHLBI) has 3 targeted funding opportunities with deadlines in February. It’s also not too early to start preparing for the April 5 Omnibus solicitation deadline. Check your registrations (SAM must be renewed annually!) and reach out to discuss your project.

For questions about the NHLBI SBIR/STTR programs, contact Small Business Coordinator Jennifer Shieh, PhD at This email address is being protected from spambots. You need JavaScript enabled to view it.

Human Cellular Models for Predicting Individual Responses to CFTR-Directed Therapeutics— Due February 9

For the development and validation of novel in vitro human cell-based tools for predicting the responses of individual patients to cystic fibrosis transmembrane conductance regulator (CFTR)-directed therapeutics for cystic fibrosis lung disease.

SBIR: RFA-HL-15-027 STTR: RFA-HL-15-026

For questions about these funding opportunities, contact:
Robert Smith, PhD, This email address is being protected from spambots. You need JavaScript enabled to view it.
Program Director, Division of Lung Diseases

Development of a Microfluidic Platform for Blood Testing in Neonatal & Pediatric Patients— Due February 10 (Phase II only)

For the development of microfluidic devices to analyze blood for factors related to the thrombotic, transfusion, and/or hemostatic status of pediatric/neonatal patients.

SBIR—Phase II only: RFA-HL-14-026
This application must be based on an awarded SBIR or STTR-funded Phase I project.

For questions about this funding opportunity, contact:
Ronald Warren, PhD, This email address is being protected from spambots. You need JavaScript enabled to view it.
Program Director, Division of Blood Diseases and Resources

Stem Cell-Derived Blood Products for Therapeutic Use: Technology Improvement— Due February 20

For tools and technologies that enable further advances in the manufacturing process to produce safe and functional blood and platelet products at reduced costs.

SBIR: RFA-HL-15-030 STTR: RFA-HL-15-029

Slides from the January 8 webinar are available—please send a request to This email address is being protected from spambots. You need JavaScript enabled to view it..

For questions about these funding opportunities, contact:
Shimian Zou, PhD, This email address is being protected from spambots. You need JavaScript enabled to view it.
Program Director, Division of Blood Diseases and Resources

John Thomas, PhD, This email address is being protected from spambots. You need JavaScript enabled to view it.
Program Director, Division of Blood Diseases and Resources

Startup Maryland (www.startupmd.org) today announced appointment of serial entrepreneur Shahab Kaviani as Entrepreneur-in-Residence (EiR).

A recognized leader of startup communities globally, Kaviani brings over a decade of first-hand entrepreneurial expertise and leadership experience most-recently as co-founder and CEO of Rockville, MD based CoFoundersLab (now Onevest). Previously, Kaviani served on the executive management team growing another Maryland company, HyperOffice, into a cloud-collaboration software leader.

PharmAthene Inc. now knows how much money it stands to get in its long-running lawsuit with Siga Technologies Inc.: A judge Thursday said Siga must pay PharmAthene $195 million and $30,663 per day in interest if Siga loses its appeal to the Delaware Supreme Court.

The case dates to 2006, when Annapolis-based PharmAthene sued New York-based Siga after the companies' planned merger fell apart. PharmAthene claimed it was entitled to some of the profits from Tecovirimat, Siga's smallpox antiviral.

Nick Culbertson was a Green Beret. Robert Lord worked at a hedge fund in Connecticut. Then after a career change, both found themselves in medical school at Johns Hopkins University. But while there, the pair met and discovered a much greater need.

The most significant announcement that Apple made in 2014 wasn’t a larger-sized iPhone. It was that Apple is entering the health-care industry. With HealthKit, it is building an iTunes-like platform for health; Apple Watch is its first medical device. Apple is, however, two steps behind Google, IBM, and hundreds of startups. They realized much earlier that medicine is becoming an information technology and that the trillion-dollar health-care market is ripe for disruption.

Alexandria Real Estate Equities, the largest owner and developer of real estate for the life-sciences industry in the nation wants to raise up to $20 million to build digital health startups in San Francisco, SFGate reports. Last year, the real estate developer announced that it would start three new accelerators nationwide to focused on agriculture, biotech and digital health. The biotech space is already up and running in New York City and has attracted giant pharma companies such as Pfizer Inc. and Eli Lily & Co with $51 million in funding. The agriculture space is scheduled to open later this year in North Carolina. 

Roche said today it will acquire Trophos for up to €470 million (about $543 million), in a deal that will expand the pharma giant’s portfolio in neuromuscular disease with high medical need, anchored by the Phase II/III-completed spinal muscular atrophy (SMA) compound olesoxime (TRO19622).

AOL founder Steve Case predicted last January that the region east of the Mississippi River would raise more venture capital than Silicon Valley in 2014.

And the winner is … Silicon Valley. By a friggin' landslide.

Please join us in wishing her well as she embarks on retirement and new adventures.

When:

January 20, 2015 4:30 p.m. - 6:00 p.m. (Remarks at 5:15 p.m.) La Tasca - Baltimore - 201 East Pratt St. (Parking validated at 100 Pratt St.- $5) Cash bar; light horse d'euvres

and/or

January 28, 2015 4:00 p.m. - 5:00 p.m. (Remarks at 4:15 p.m.; BioBuzz networking 'til 7:30 p.m.) Growlers - Gaithersburg - 227 West Diamond St. Cash bar; light horse d'euvres

Venture capital funding hit its highest annual mark since 2001 as venture investors participated in $47.3 billion across 3,617 deals. Even versus 2013, the past year was huge as venture capital skyrocketed 62% YoY due to multiple $500M+ mega-rounds while deal growth was more modest, climbing 8%. Of note, two quarters each – Q2’14 and Q4’14 – notched over $13B in funding.

All that venture capital money so famously "sitting on the sideline" finally made it into company coffers in 2014.

Mark McCaffrey, a partner at PriceWaterhouseCoopers, called 2014 an "exciting year" for venture capital investing, where two deals exceeded $1 billion and 40 "megadeals" exceeded $100 million.

All of us here at Startup Maryland are very excited to invite you to Collaborate, an innovation conference we're participating in January 23rd & 24th in Washington DC.

"Startup Maryland is delighted to be in the Resource Expo showcasing our initiatives around Celebration, Connections, Coaching and Capital.," stated Michael Binko, founder and president of Startup Maryland. "We'll be highlighting the results of the third-annual Pitch Across Maryland, our upcoming Raise Your Game bootcamp for entrepreneurs and our plans to engage side-line angel investors across the region," added Binko.

January 30th, 2015 8:00 AM-10:00 AM

Learn from Eitan Yudilevich, Ph.D. Director of U.S. - Israel Binational R & D Foundation (BIRD) about grants available to collaborate new high tech product development with Israeli companies. Grants up to $1 million are available to engage innovative companies from The Start Up Nation to kick start your company’s product development to a new level.While there is no fee, RSVPs are required.

New Jersey's first private medical school in 50 years is planned for part of the 110-acre Hoffmann-La Roche property. Roche plans to vacate the land in 2015 after an 80-year history in Clifton and Nutley.

Novartis India has agreed to transfer its over-the-counter division (OTC Division) to GlaxoSmithKline Consumer (GSK CPL), a consumer healthcare joint venture (JV) between Swiss pharmaceutical firm Novartis and GSK, for about INR1.097bn ($17.6m)

The cash just keeps flowing in health IT, as does M&A activity.

According to Mercom Capital Group, venture capital in the health IT space reached $4.7 billion in 2014, up from $2.2 billion the year prior. Rock Health recently put the figure at $4 billion, although it’s count does not include deals under $2 million.

FierceBiotech on Wednesday delivered the first big verdict on the “mood” of the JP Morgan Healthcare Conference – based largely on its executive breakfast held this week in San Francisco. The verdict: Real confidence well above and beyond the typical happy face you’d get, regardless, at JP Morgan.

The Johns Hopkins University Applied Physics Laboratory (APL), in Laurel, Maryland, has received $4 million in funding from the Mann Fund to develop a next-generation retinal prosthesis system. The Mann Fund was created by philanthropist Alfred E. Mann 15 years ago to support the development of biomedical technologies.

In the summer of 2013, Pamela Shavaun Scott started having "24/7 severe headaches" — so severe that she couldn't sleep. It wasn't before December that she heard for sure that it was a brain tumor.

Harvard University has long played an outsized role in spurring the growth of the Boston area’s life sciences industry, but the school’s contributions have largely unfolded behind the scenes.

Unlike the Massachusetts Institute of Technology in Cambridge’s Kendall Square — the beating heart of biotech — Harvard has been known less for spinning off startups than for licensing cutting-edge research and grooming the industry’s business leaders.

A trio of scientists have started working with researchers at GlaxoSmitKline on a potential cure for cancer. In fact, they believe they've found the diseases' "Achilles heel."

Last month, GlaxoSmithKline (NYSE: GSK) selected a Wistar/Penn project for its 2014 Discovery Fast Track Challenge program, which was created to accelerate the development of new medicines.

A Exciting Opportunity for Investor Meetings and Showcases

SUBMISSION DEADLINE: January 21, 2015  

We invite you to submit your high-growth and innovative companies to individually meet with and showcase to an exclusive Global 1000 Transaction Network of Corporate Investors, Venture Capitalists, and Angel Investors at the Combined University Startups and Global 1000 Meet | Partner | Deal Conference in Washington, DC, on March 11 and 12, 2015.

The United States shouldn’t worry just yet about losing the number one spot as far as disease-related research in the world goes – that’s pretty solid – but that doesn’t mean the country is steadily moving forward the way it could or should.

‘Tis the season for dieting and purchasing gym memberships you may or may not use.

There are plenty of tactics out there for how to drop excess weight fast, and generally speaking, most of them probably won’t be the quick fix resolutionaries are hoping for (yes, that’s a made up word).

In 2012, we authored a report titled The Evolving Business Case for Social Media in Healthcare – a publication covering the range of social media influences on the industry.  These influences were essentially cloud-based approaches to sharing information between consumers, individual care professionals and healthcare organizations.

The Colonial Room of the St. Francis Hotel in San Francisco was filled beyond capacity Monday afternoon, and the offices of digital-health seed fund Rock Health were buzzing with hundreds of partygoers just a couple of hours later.

Swiss drugmaker Roche said on Wednesday it had entered into an agreement with QIAGEN that includes a provision of non-exclusive licenses to recently granted Roche patents, pertaining to the detection of mutations in the EGFR pathway.

In a laboratory first, Duke researchers have grown human skeletal muscle that contracts and responds just like native tissue to external stimuli such as electrical pulses, biochemical signals and pharmaceuticals.

It didn't take R. Michael Gill very long to come up with some priorities after Gov.-elect Larry Hogan named him the next Maryland Department of Business and Economic Development secretary last week.

Gill wants to keep McCormick & Co. Inc. (NYSE: MKC) in state. He wants to bring the FBI headquarters to Maryland. And he wants to emphasize customer service in dealing with businesses.

Lockheed Martin Corp. is normally known for big things – tanks, planes, ships, those kinds of projects.

But a new partnership the defense giant has formed with a San Diego company has Lockheed looking at something very, very small.