The University of Maryland (UM) BioPark announced today that Ocular Proteomics, LLC (OPL), a startup biotechnology company leveraging a new class of biomarkers found in vitreous fluid of the eye to more accurately diagnose and treat retinal diseases, has recently relocated to Building One of the BioPark from Baltimore County. Led by world-renowned and internationally respected retinal surgeon Bert M. Glaser, M.D., OPL is a spin out of the National Retina Institute. OPL’s move to the BioPark comes on the heels of the company’s $1.2 million dollar Small Business Innovation in Research (SBIR) phase 2 grant from the National Institutes of Health. In its new space, OPL will be conducting the research phase of a multi-center clinical trial, which will include 200 patients with macular degeneration.

Said Jim Hughes, President, Research Park Corporation, University of Maryland Baltimore, “The BioPark has once again attracted an innovative and important start-up to our location. We’re pleased to welcome Dr. Glaser and Ocular Proteomics to our roster of commercial tenants. Dr. Glaser founded Ocular Proteomics to use personalized medicine to drastically change the way blinding diseases are diagnosed and treated.”

It’s a popular sport among startups and the mobile vendor community to figure out what physicians are willing to do on their tablets and smartphones. It has to be said that some of them have come up with some pretty compelling approaches to deepen the relationship between physicians and their mobile devices.

But what is really going on in their practices? In two studies generated from a survey by AmericanEHRPartners of 1,400 with responses from about 696 physicians and 150 allied health professionals has uncovered some interesting information. AmericanEHRPartners was formed in 2010 by formed by Cientis Technologies and the American College of Physicians to help physicians compare and implement electronic health records.

Irene Pollin, the widow of the late Washington sports team owner Abe Pollin, has donated $10 million to a Johns Hopkins University center for the prevention of heart disease.

Hopkins announced Thursday that Pollin’s gift will support the Ciccarone Center for the Prevention of Heart Disease in the division of cardiology.

Aside from memory loss and cognitive impairments, often the most difficult aspect of caring for people with dementia is treating their disruptive changes in behavior.

With no reliable medications to treat them and limited information for caregivers regarding alternative therapies, these behavior changes are frequently the source of increased upset, stress and burden to families and often result in nursing home placement.

Robert Langer shares the experiences and lessons learned through his involvement with more than two dozen biotech startups.

I started my first company in 1987 because I realized it was an effective path for transforming science into life-saving and life-improving inventions. Startup companies provide one means for accomplishing ends that interested me: creating products that have a positive effect on human health. I did this first with a colleague (Box 1), but through the years I have also started many companies with students and postdocs in my MIT lab.

Many times when I talk with small businesses, they don't fully understand the difference between a Federal Grant and a Federal Contract. It is important for a small business to completely understand if their government funds are coming from a grant or a contract.  The terms and conditions surrounding each have somewhat unique requirements that may have implications on how the business handles the award and, in particular, the accounting related to that award. 

The Government defines the difference in fairly easy to understand terms (for the government) at the grants.gov website:

A Grant is an award of financial assistance, the principal purpose of which is to transfer a thing of value from a federal agency to a recipient to carry out a public purpose of support or stimulation authorized by a law of the United States (see 31 U.S.C. 6101(3)). A grant is distinguished from a contract, which is used to acquire property or services for the federal government's direct benefit or use.

The NIH is one of the 'easier' federal agencies to apply to because every year it issues an Omnibus Solicitation, requesting investigator- initiated topics. This means that rather than telling you exactly which projects they will fund, the NIH asks you, the investigator, to come up with the ideas.

As long as these ideas are related to Human Health, have the requisite level of Technological Innovation and Commercial Potential, they may be appropriate for SBIR/STTR. However, you still need to do some homework to make sure your idea fits within the research interests of the NIH's Institutes and Centers. So before you put a lot of work into developing your proposal, there are a few things you can do:

In the year following its groundbreaking last June, all aspects of Bioscience Connecticut have moved forward on time and on budget. Of note, the project has created about 500 construction and related jobs on the UConn Health Center campus in its first year, including higher-than-required averages for small business participation and 85 percent of all work going to Connecticut-based contractors. The number of construction jobs will rise significantly over the next three years.

“Bioscience Connecticut was an important first step in positioning Connecticut as a leader in the industry,” said Governor Dannel P. Malloy. “This investment, in conjunction with the new Bioscience Innovation Fund and our other efforts, not only creates thousands of good paying jobs with good benefits, but also highlights the commitment we have to growing this sector of our economy. Our vigorous approach to establishing long-term partnerships between our universities, medical centers, and private secto

University of Maryland, Baltimore campus President Jay A. Perman, M.D., and University of Maryland School of Medicine Dean E. Albert Reece, M.D., Ph.D., M.B.A., wish to announce the establishment of a new center to unite research scientists and physicians across disciplines. The center will employ these interdisciplinary connections to enhance the use of cutting edge medical science such as genomics and personalized medicine to accelerate research discoveries and improve health care outcomes. Participants in the new University of Maryland Center for Health-Related Informatics and Bioimaging (CHIB) will collaborate with computer scientists, engineers, life scientists and others at a similar center at the University of Maryland, College Park campus, together forming a joint center supported by the M-Power Maryland initiative.

University of Maryland School of Medicine Dean E. Albert Reece, M.D., Ph.D., M.B.A., with the concurrence of President Perman, has appointed as co-director of the new center Owen White, Ph.D., Professor of Epidemiology and Public Health and Director of Bioinformatics at the University of Maryland School of Medicine Institute for Genome Sciences.

Emory University has launched a public-private drug development enterprise that will transition scientific discoveries more rapidly and efficiently from university laboratories into the marketplace. The new venture is expected to help address worldwide drug development and commercialization needs.

Drug Innovation Ventures at Emory, LLC (DRIVE) is a not-for-profit company separate from, but wholly owned by Emory.

On Tuesday, GE Healthcare announced plans to invest $2 billion over the next five years on the development of software for health systems and applications, Healthcare IT News reports.

To develop the software, the company will work with the GE Software Center of Excellence in San Ramon, Calif., in addition to several other research and development firms across the world (Monegain, Healthcare IT News, 6/12).

On May 31, the Department of Health and Human Services (HHS) reissued its Omnibus Funding Opportunity Announcement (FOA) for the Small Business Innovation Research (SBIR) and the Small Business Technology Transfer (STTR) programs in order to implement venture capital provisions of the SBIR/STTR Reauthorization Act of 2011.

HHS notice NOT-OD-13-071 will allow small business concerns that are majority-owned by multiple venture capital operating companies (VCOCs), hedge funds and/or private equity firms to apply for the NIH SBIR program and compete for up to 25 percent of NIH’s SBIR set-aside in the Omnibus FOA or any other NIH SBIR funding announcement issued hereafter. With this notice, NIH is the first agency to elect to use its authority under Section 5107 of the reauthorization to make awards to majority-owned firms, signaling new and significant opportunities for venture capital in the future.

UK pharmaceutical company AstraZeneca plc (LSE:AZN) is the second bidder for the dedicated biotech incubator being set up by the Chief Scientist's incubator program at the Ministry of the Economy, sources inform "Globes."

The company will bid for the incubator tender against a consortium of OrbiMed venture capital fund and healthcare giant Johnson & Johnson (NYSE: JNJ).

HHS Secretary Kathleen Sebelius opens Health Datapalooza IV with an emphatic introduction speech asking those in attendance to continue driving more ideas and innovation in data and information exchange to improve the future of the US health system.

The Economic Alliance of Greater Baltimore (EAGB) and Maryland Department of Business of Economic Development (DBED) have announced the creation of Advance Maryland, a business program designed to support growth companies, an integral component in the prosperity and sustainability of local economies. Advance Maryland was established to provide resources targeted to second-stage companies.  These companies are growth-oriented and have moved beyond the startup phase. They are at the forefront of job creation and critical to vibrant economies. In contrast to traditional business assistance which focuses on finances, business plans and operational issues,

Advance Maryland addresses strategic growth challenges, from developing new markets and refining business models, to gaining access to competitive intelligence. “Maryland has a plethora of organizations and resources devoted to the startup community, but we are limited when it comes to resources for second stage companies. The statistics show how essential it is to recognize these companies and make the necessary tools available to support their growth,” stated Jen Gunner, COO of EAGB and Co-Program Manager of Advance Maryland. Youreconomy.com states that between 1995 and 2009, second-stage companies represented eleven percent of U.S. establishments, but generated more than thirty six percent of jobs and thirty eight percent of sales.

Histogenics Corp., a regenerative medicine company that combines cell therapy and tissue engineering technologies to develop highly innovative products primarily for orthopedic tissue repair, today announced the appointment of Peter Greenleaf to Chief Executive Officer.

Bringing over 20 years of experience in the biotechnology industry to Histogenics, Mr. Greenleaf most recently served as President of MedImmune, the worldwide biologics arm of AstraZeneca. During his tenure, he presided over the expansion of MedImmune's extensive growth and pipeline and spearheaded industry-leading business development and venture deals. Mr. Greenleaf also served as the President of MedImmune Ventures, overseeing more than $300 million in investments in early stage portfolio companies. Prior to becoming President, Greenleaf led the development of the company's global marketing and portfolio organizations and managed the broader commercial, corporate development and strategy functions.

The D.C. region is home to some 765,000 jobs that require knowledge in science, technology, engineering and math, representing 27 percent of the overall workforce, according to a report released Monday by the Brookings Institution. Only Silicon Valley ranked higher in percentage of STEM labor.

Greater Washington has consistently ranked near or at the top of the nation in STEM job rankings, owing largely to the federal government and the contracting industry surrounding it, which grew rapidly following the Sept. 11 terrorist attacks. The region also boasts a substantial cluster of commercial tech companies - many of them situated along the Dulles corridor and Interstate 270 - as well as a small but growing software startup scene.

Almost a quarter of the jobs in the Baltimore-area are science, technology, engineering and math positions, according to a new report by the Brookings Institution.

A total of 281,730 local STEM jobs account for about 23 percent of workforce in the Baltimore-Towson region. Baltimore ranks eighth out of 100 metropolitan areas for its concentration of STEM jobs in the Metropolitan Policy Program study released Monday by the Washington, D.C., think tank.

Five to ten years.  That’s how long it will be before drug reimbursement in the United States becomes as stringent as in Europe, according to a range of consultants, analysts, and health policy experts with whom I’ve spoken.

This new reimbursement environment – and the expectations leading up to it – is expected to emphasize the value of “profound” innovation, at the expense of less dramatic, incremental innovation.

Maryland is No. 1 — or is it No. 7? On third thought, it might be 41st.

Critics and champions of the Free State’s business climate and tax policy have plenty to argue about most days, and all-over-the-place business climate rankings do little to quell the conflict.

The U.S. Chamber of Commerce last month rated Maryland No. 1 for entrepreneurship and innovation, piling on to an Entrepreneur Magazine ranking calling Maryland the best state in which to start a business.

Big pharmaceutical companies strike licensing deals with small companies in hopes of finding new, highly profitable medicine without the cost of buying a whole company.

Small companies get funding other ways, such as venture capital firms, but the money from licensing arrangements can mean the difference between continuing operations and closing shop.

The NHLBI Division of Extramural Research Activities (DERA) is pleased to announce the addition of Dr Lawrence Mahan, as the Director of the Office of Translational Alliances and Coordination (OTAC). Dr. Mahan’s professional experience spans academia, government and industry in both basic and ap­plied biomedical research. Additionally it includes global business and strategic alliance development, strategic planning, technology evaluation, entrepreneurship guidance, and consulting on platform technology development in the life sciences.

Most recently Dr. Mahan served as Director of Innovation and Business Development for Children’s National Medical Center and its research institutes, the Children’s Research Institute and the Sheikh Zayed Institute for Pediatric Surgical Innovation, where he managed intellectual property, strategic business alliance development and the advancement of academic entrepreneurship.

Investing in biotechnology is a riskier bet these days. The community of life sciences venture capital firms is contracting, despite scientific advances across many fields like genomics, immunology, and diagnostics. Many promising new enterprises fail to produce marketable drugs, and even successful therapies may struggle to gain markets in an environment of health care cost cutting.

That’s exactly why Johnson & Johnson (NYSE: JNJ) chose to expand its programs that nurture very early stage biotechnology and device startups in the Bay area, J&J executives said as they opened the company’s California Innovation Center in Menlo Park, CA, this week.

The following funding opportunity announcements from the NHLBI or other components of the National Institutes of Health, might be of interest:

NIH Guide Notices:

• NOT-OD-13-075: NIH Announces an Adjustment to Transition Timeline for Electronic Submission of Multi-Project Application
• NOT-OD-13-074: NIH to Require Use of Updated Electronic Application Forms for Due Dates on or after September 25, 2013
• NOT-OD-13-073: Notice of Change in Application Due Date for RFA-OD-13-009 Short Courses on Innovative Methodologies in the Behavioral and Social Sciences (R25)
• NOT-OD-13-071: HHS Reissues PHS 2013-02 SBIR and STTR Omnibus Grant Solicitations Implementing Venture Capital Provision and SBA Company Registry Requirement of the SBIR/STTR Reauthorization Act of 2011

Program Announcements (PA):

• PA-13-235: Reissue PHS 2013-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]) (expires January 8, 2014)
• PA-13-234: Reissue PHS 2013-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) (expires January 8, 2014)
• PAR-13-233: Chronic Inflammation and Age-related Disease (R01) (expires September 8, 2014)

Please note that most links to RFAs, PAs, and Guide Notices will take you to the NIH Web site. RFPs will take you to FedBizOpps. Links to RFPs will not work past their proposal receipt date. Archived versions of RFPs posted on FedBizOpps can be found on the FedBizOpps site using the FedBizOpps search function. Under “Document to Search,” select Archived Documents.

Pathologists and clinical laboratory professionals who regularly analyze images will be interested in the findings of a research study designed to assess how the phenomenon called “inattentional blindness” among radiologists could cause them to possibly miss things hiding in plain sight.

‘Inattentional Blindness’ Occurs Even Among Highly-trained Radiologists

In a recent study, psychological scientists from Harvard’s Brigham and Women’s Hospital found that 83% of radiologists didn’t notice an image of a gorilla embedded in a computed tomography (CT) lung scan.

 University of Maryland (UM) Ventures and SilcsBio, LLC announced today that SilcsBio has obtained exclusive rights to a technology licensed from the University of Maryland, Baltimore (UMB). UM Ventures is an ambitious joint research commercialization effort of the UMB and the University of Maryland, College Park (UMCP). SilcsBio is a supplier of computer-directed drug discovery software and services.

"The license, which we obtained from UMB, creates the core of our product line," said Kelli Booth, SilcsBio's Chief Operating Officer. "It's great to have a university so supportive of our state's start-up community."

Health Tech Hatch, a site launched last fall as a crowdfunding site specifically for health startups, is joining forces with one of the biggest crowdfunding platforms on the web, Indiegogo.

From the beginning, the company planned to help health startups both crowdfund and beta test their products with patients and physicians. But now, founder and CEO Patricia Salber said Health Tech Hatch plans to focus more closely on the beta testing side, while working on the crowdfunding piece through Indiegogo.

Through collaboration between Johnson & Johnson Innovation and the California Institute for Quantitative Biosciences (QB3), Janssen will create a 5,000-square-foot lab space within QB3’s 24,000-square-foot incubator space in San Francisco.

The company said that the new Bay Area incubator will use the San Diego model for its innovation space.

Governor Martin O’Malley today announced that Rachel King, co-founder and CEO of GlycoMimetics in Gaithersburg, has been named chair of the Maryland Life Sciences Advisory Board (LSAB). King will replace chair H. Thomas Watkins, former President and Chief Executive Officer of Human Genome Sciences, Inc., who has served on the Board since Governor O’Malley and the Maryland General Assembly created it in 2007. As chair, Watkins led the Board through a strategic planning process that, working closely with Governor O’Malley, resulted in BioMaryland 2020, a 10-year, $1.3 billion strategy for moving Maryland’s life sciences industry forward.

In a first-of-its-kind operation in the United States, a team of doctors at Duke University Hospital helped create a bioengineered blood vessel and transplanted it into the arm of a patient with end-stage kidney disease.  

The procedure, the first U.S. clinical trial to test the safety and effectiveness of the bioengineered blood vessel, is a milestone in the field of tissue engineering. The new vein is an off-the-shelf, human cell-based product with no biological properties that would cause organ rejection.  

NIH has reissued its Small Business Innovation Research (SBIR) Omnibus Grant Solicitation announcement, which states that small businesses that are majority-owned by multiple venture capital operating companies are eligible to apply for (1) these SBIR grants and (2) any other NIH SBIR funding opportunities announced after January 28, 2013.  The NIH grant solicitation announcement can be found here.

With this re-issuance, small businesses that are majority-owned by multiple venture capital operating companies (VCOCs), hedge funds and/or private equity firms are now eligibleto apply to the NIH SBIR program and compete for up to 25% of NIH’s SBIR set-aside.

Healthcare providers are taking telemedicine to new heights, with the market seeing growth of a whopping 237 percent within a five-year period, according to a new Kalorama report.

Officials say the telemedicine patient monitoring market grew from $4.2 billion in 2007 to more than $10 billion in 2012. According to the report, the market itself is considered small- to moderate in size but makes up for it with its notable number of competitors and "increasing awareness of effectiveness."

More than 60 companies showed off their health data applications at Datapalooza IV this week and Krishna Yeshwant, a partner at Google Ventures, was the MC for a demo session on Tuesday afternoon.

As one of the presenters was fighting with his PowerPoint demonstration and the projection system, Yeshwant answered a few questions about opportunities for healthcare startups with the search company’s investment group. He said that the outlook has changed for healthcare IT startups now that Obamacare is here to stay.